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      <JournalTitle>Frontiers in Medical Case Reports</JournalTitle>
      <Volume-Issue>Volume 1; Issue 2</Volume-Issue>
      <Season>(Mar-Apr, 2020)</Season>
      <ArticleType>Medical Case Reports</ArticleType>
      <ArticleTitle>Successful Ozone Treatment of EBV and HSV-Related Viral Urticaria</ArticleTitle>
      <Abstract>Urticaria is a many-sided syndrome signed by itching, itchy red swelling and/or angioedema related to: parasites, autoimmune diseases, food intolerance, stress, viruses, physical and unfound causes (idiopathic). We reported the successful Ozone treatment of two cases of viral-related urticaria-angioedema. Case 1: a 49 years-old woman also suffering from Hashimoto autoimmune thyroiditis showed a significant increase of EBVNA-Ab and EBVCA-Ab IgG (&gt;10 times the cut-off levels). The symptom VAS was 10/10 at the start, 4/10 after the third treatment and 0/10 after ten treatments; UAS7 was 42 at the start of the therapy, fifteen after 2 weeks, 0 after 5 weeks. Case 2: a 58 years-old man was treated for 5 months in hospital with steroids and omalizumab without any clinical improvement at all. He showed a significant increase of EBVNA-Ab and EBVCA-Ab and HSV1-Ab IgG (&gt;10 and &gt;20 times the cut-off levels respectively). The symptom VAS was 10/10 at the start, 2/10 after the third treatment, withdrawing steroid therapy, and 0/10 after the sixth treatment; the UAS7 was 42 at the start, ten after 2 weeks, 0 after 3 weeks. The treatment was the Small Ozonized Autohemo Therapy (SOAT) (10 ml of oxygen-ozone treated peripheral venous blood was reinjected into the patient’s gluteus); the treatment was repeated twice a week for 5 weeks. It’s well known the ozone is the most powerful natural mean pathogen killing, including viruses and bacteria; this chemical agent is many times more active than chlorine. The used ozone maker machine was Humazone from Humares (Salute OK, Rome) allowing precise photometric ozone concentration’s choice. SOAT of viral-related urticaria is effective thanks to antiviral action of ozone, acting as autovaccine.</Abstract>
      <Keywords>EBV,HSV,Viral Urticaria</Keywords>
        <Abstract>https://jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=7211&amp;title=Successful Ozone Treatment of EBV and HSV-Related Viral Urticaria</Abstract>
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