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    <Journal>
      <PublisherName>jmedicalcasereports</PublisherName>
      <JournalTitle>Frontiers in Medical Case Reports</JournalTitle>
      <PISSN>I</PISSN>
      <EISSN>S</EISSN>
      <Volume-Issue>Volume 7; Issue 5</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>(Sep-Oct, 2026)</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>2026</Year>
        <Month>09</Month>
        <Day>24</Day>
      </PubDate>
      <ArticleType>Medical Case Reports</ArticleType>
      <ArticleTitle>Exploring the Therapeutic Potential of Repetitive Transcranial Magnetic Stimulation (rTMS) in Ophthalmic Comorbidities</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>1</FirstPage>
      <LastPage>12</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Shaurya</FirstName>
          <LastName>Mahajan</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Sanjay</FirstName>
          <LastName>Thunga</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Noah St.</FirstName>
          <LastName>Clair</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Siddhesh</FirstName>
          <LastName>Jakkaraju</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Yolanda</FirstName>
          <LastName>Belickis</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Farah</FirstName>
          <LastName>Issa</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Krrishika</FirstName>
          <LastName>Saxena</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Vipul</FirstName>
          <LastName>Reddy</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Charles</FirstName>
          <LastName>Vigilia</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Keerthy</FirstName>
          <LastName>Sunder</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>Symptomatic vitreous opacities (SVO) and macular degeneration (MD) are associated with elevated rates of depression and anxiety, yet the psychological burden of these ophthalmic conditions often persist despite standard pharmacologic treatment. We present three cases__ampersandsignmdash;two with MD and one with SVO__ampersandsignmdash;of treatment-resistant major depressive disorder treated with repetitive transcranial magnetic stimulation (rTMS) targeting the dorsolateral prefrontal cortex (DLPFC). Each patient completed 36 sessions of bilateral DLPFC rTMS over 6__ampersandsignndash;8 weeks following failed antidepressant trials. PHQ-9 and GAD-7 scores were tracked weekly, with all three patients demonstrating substantial symptom reduction (PHQ-9 decreases of 70__ampersandsignndash;93.8%; GAD-7 decreases of 83.3__ampersandsignndash;100%) and no adverse events. To our knowledge, based on a targeted literature search, no prior published cases have evaluated rTMS for depression in the context of SVO/MD. These preliminary observations suggest rTMS may serve as an effective adjunctive treatment for psychiatric symptoms in patients with chronic visual disturbances and co-occurring psychological distress, warranting further investigation in larger cohorts.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Symptomatic Vitreous Opacities (SVO), Macular Degeneration (MD), Repetitive Transcranial Magnetic Stimulation (rTMS), Generalized Anxiety Disorder 7-item scale (GAD-7), Patient Health Questionnaire-9 (PHQ-9)</Keywords>
      <URLs>
        <Abstract>https://jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=16386&amp;title=Exploring the Therapeutic Potential of Repetitive Transcranial Magnetic Stimulation (rTMS) in Ophthalmic Comorbidities</Abstract>
      </URLs>
      <References>
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    </Journal>
  </Article>
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