<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>jmedicalcasereports</PublisherName> <JournalTitle>Frontiers in Medical Case Reports</JournalTitle> <PISSN>I</PISSN> <EISSN>S</EISSN> <Volume-Issue>Volume 6; Issue 1</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>(Jan-Feb, 2025)</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>-0001</Year> <Month>11</Month> <Day>30</Day> </PubDate> <ArticleType>Medical Case Reports</ArticleType> <ArticleTitle>NSAID Induced Spontaneous Rectal Perforation</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>1</FirstPage> <LastPage>6</LastPage> <AuthorList> <Author> <FirstName>Maheen</FirstName> <LastName>Rana</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> <FirstName>Patricia</FirstName> <LastName>Pantilie</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Ben</FirstName> <LastName>O’Sullivan</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Robert</FirstName> <LastName>Hannon</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI/> <Abstract>NSAID related spontaneous rectal perforation is a rare and severe condition with potentially life-threatening outcomes. We report a case of a 75-year-old woman with a mid-rectal perforation related to prolonged NSAID use. She presented with sudden rectal and lower abdominal pain. Imaging revealed a localised gas collection in the pre-sacral space without widespread peritonitis. Management included laparoscopic loop sigmoid colostomy and IV antibiotics. The patient recovered well and showed complete resolution at follow-up. This case highlights the importance of judicious use of NSAIDS in high-risk patients and underscores the need for individualised management strategies.</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>NSAID,Spontaneous Rectal Perforation,Sigmoidoscopy</Keywords> <URLs> <Abstract>https://jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=15560&title=NSAID Induced Spontaneous Rectal Perforation</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References>Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem Pharmacol 2020; 180: 114147. Bjarnason I, Scarpignato C, Holmgren E, Olszewski M, Rainsford KD, Lanas A. Mechanisms of Damage to the Gastrointestinal Tract from Nonsteroidal Anti-Inflammatory Drugs. Gastroenterology 2018; 154: 500-514. Kamboj AK, Moreira RK, Sweetser S. NSAID-Induced Colopathy. Mayo Clin Proc 2021; 96: 2724-2725. Meshikhes HA, Duhaileb MA, Alzahir AA, Almomen SA, Meshikhes AN. Obscure Gastrointestinal Bleeding Due to Non-steroidal Anti-inflammatory Drug-Induced Colopathy. Cureus 2021; 13: e20278. Tai FWD, McAlindon ME. Non-steroidal anti-inflammatory drugs and the gastrointestinal tract. Clin Med (Lond) 2021; 21: 131-134. Watanabe T, Fujiwara Y, Chan FKL. Current knowledge on non-steroidal anti-inflammatory drug-induced small-bowel damage: a comprehensive review. J Gastroenterol 2020; 55: 481-495. Wiesler B, Linke KS, Delko T. Rare case of an 83-year-old woman with transrectal small bowel evisceration caused by spontaneous rectal perforation. BMJ Case Rep 2022; 15: e246965.</References> </References> </Journal> </Article> </ArticleSet>