<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>jmedicalcasereports</PublisherName> <JournalTitle>Frontiers in Medical Case Reports</JournalTitle> <PISSN>I</PISSN> <EISSN>S</EISSN> <Volume-Issue>Volume 5; Issue 5</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>(Sep-Oct, 2024)</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>2024</Year> <Month>09</Month> <Day>24</Day> </PubDate> <ArticleType>Medical Case Reports</ArticleType> <ArticleTitle>Emerging Therapeutic Approaches to Drug-Resistant Tuberculosis: A Case Report and Review of Novel Treatments</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>1</FirstPage> <LastPage>5</LastPage> <AuthorList> <Author> <FirstName>Ashish</FirstName> <LastName>Pandey</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI/> <Abstract>Drug-resistant tuberculosis (DR-TB), particularly multidrug-resistant tuberculosis (MDR-TB), poses a major global health challenge. Conventional treatment regimens are long, toxic, and often ineffective. This case report describes a 32-year-old male patient with MDR-TB unresponsive to standard therapies, successfully treated using a novel combination of repurposed drugs, immunomodulators, and bacteriophage therapy. Sputum cultures converted to negative within three months, with sustained clinical and radiological improvement over 12 months. The review further discusses the integration of artificial intelligence (AI) in optimizing treatment regimens, a promising but underexplored area in MDR-TB management. This case underscores the need for innovative therapeutic approaches to improve outcomes in DR-TB.</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>Multidrug-Resistant Tuberculosis,Repurposed Drugs,Immunomodulation,Phage Therapy,Artificial Intelligence,Drug Development,Tuberculosis Treatment</Keywords> <URLs> <Abstract>https://jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=15377&title=Emerging Therapeutic Approaches to Drug-Resistant Tuberculosis: A Case Report and Review of Novel Treatments</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References>Abedon ST, Garcand;iacute;a P, Mullany P, Aminov R. Editorial: Phage Therapy: Past, Present and Future. Front Microbiol 2017;8: 981. Cox H, Ford N. Linezolid for the treatment of complicated drug-resistant tuberculosis: a systematic review and meta-analysis. 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