<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
      <JournalTitle>Frontiers in Medical Case Reports</JournalTitle>
      <Volume-Issue>Volume 3; Issue 5</Volume-Issue>
      <Season>(Sep-Oct, 2022)</Season>
      <ArticleType>Medical Case Reports</ArticleType>
      <ArticleTitle>Acute Spinal Cord Dysfunction Following COVID-19 Infection: A Case Report</ArticleTitle>
      <Abstract>Here, we describe a 44-year-old female that developed abrupt symptomatology, including lower-limb paralysis with sensory involvement at the T12 level, two weeks after the resolution of COVID-19 bilateral pneumonia. Based on the neurological symptoms and the neurophysiological investigations, a clinical diagnosis of thoracic spinal cord dysfunction was made. However, all the complementary tests performed showed normal results. In particular, repeated MRIs showed no alterations; the cerebrospinal fluid analysis showed normal results: the CT scan of the brain was normal and the CT scan of the abdominal and thoracic aorta showed a normal size and course. Cases of spinal cord involvement have rarely been described, in which the MRIs never revealed cord signaling changes. We hypothesize that a small vessel spinal cord stroke might explain the pathogenesis and the absence of changes detectable on an MRI along with the patient__ampersandsign#39;s modest recovery during the long follow up. However, it cannot be excluded that the severe clinical course of SARS-CoV-2 infection, may suggest other different etiologies that could be related to prolonged hospitalization.</Abstract>
      <Keywords>COVID-19,Spinal Cord Dysfunction,Lower-limb Paresis</Keywords>
        <Abstract>https://jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=14062&amp;title=Acute Spinal Cord Dysfunction Following COVID-19 Infection: A Case Report</Abstract>
        <References>Abrams RMC, Safavi F, Tuhrim S, Navis A, Steinberg J, Shin SC. MRI negative myelopathy post mild SARS-CoV-2 infection: vasculopathy or inflammatory myelitis? J Neurovirol 2021; 27: 650-655.&#13;
Eissa M, Abdelhady M, Alqatami H, Salem K, Own A, El Beltagi AH. Spinal cord infarction in a 41-year-old male patient with COVID-19. Neuroradiol J 2021; 34: 245-248.&#13;
Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, Kneen R, Defres S, Sejvar J, Solomon T. Neurological associations of COVID-19. Lancet Neurol 2020; 19: 767-783.&#13;
Garg RK, Paliwal VK, Gupta A. Spinal cord involvement in COVID-19: A review. J Spinal Cord Med 2021; 11: 1-15.&#13;
Khair AM, Nikam R, Husain S, Ortiz M, Kaur G. Para and Post-COVID-19 CNS Acute Demyelinating Disorders in Children: A Case Series on Expanding the Spectrum of Clinical and Radiological Characteristics. Cureus 2022;14: e23405.&#13;
McFadyen JD, Stevens H, Peter K. The emerging threat of (Micro) thrombosis in COVID-19 and its therapeutic implications. Circ Res 2020; 127: 571–587.&#13;
Mondal R, Deb S, Shome G, Ganguly U, Lahiri D, Benito-Leand;ograve;n J. COVID-19 and emerging spinal cord complications: A systematic review. Mult Scler Relat Disord 2021; 51: 102917.&#13;
Nath A. Neurologic complications of coronavirus infections. Neurology 2020; 94: 809-810.&#13;
Salamanna F, Maglio M, Landini MP, Fini M. Platelet functions and activities as potential hematologic parameters related to Coronavirus Disease 2019 (Covid-19). Platelets 2020; 31: 627-632.&#13;
Sampogna G, Tessitore N, Bianconi T, Leo A, Zarbo M, Montanari E, Spinelli M. Spinal cord dysfunction after COVID-19 infection. Spinal Cord Ser Cases 2020; 6: 92.&#13;
Scotti G and Gerevini S. Diagnosis and differential diagnosis of acute transverse myelopathy. The role of neuroradiological investigations and review of the literature. Neurol Sci 2001; 22: S69–S73.&#13;
Studart-Neto A, Guedes BF, Tuma RLE, Camelo Filho AE, Kubota GT, Iepsen BD, Moreira GP, Rodrigues JC, Ferrari MMH, Carra RB, Spera RR, Oku MHM, Terrim S, Lopes CCB, Passos Neto CEB, Fiorentino MD, DE Souza JCC, Baima JPS, DA Silva TFF, Moreno CAM, Silva AMS, Heise CO, Mendonand;Ccedil;a RH, Fortini I, Smid J, Adoni T, Gonand;Ccedil;alves MRR, Pereira SLA, Pinto LF, Gomes HR, Zanoteli E, Brucki SMD, Conforto AB, Castro LHM, Nitrini R. Neurological consultations and diagnoses in a large, dedicated COVID-19 university hospital. Arq Neuropsiquiatr 2020; 78: 494-500.&#13;
Szegedi I, Orband;aacute;n-Kand;aacute;lmand;aacute;ndi R, Csiba L, Bagoly Z. Stroke as a Potential Complication of COVID-19-Associated Coagulopathy: A Narrative and Systematic Review of the Literature. J Clin Med 2020; 9: 3137.&#13;
Tang X and Zheng F. A review of ischemic stroke in COVID-19: currently known pathophysiological mechanisms. Neurol Sci 2022; 43: 67–79.</References>