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FRONTIERS IN MEDICAL CASE REPORTS - Volume 2; Issue 3, (May-Jun, 2021)

Pages: 1-09

Importance of Alpha Lipoic Acid (ALA): Antidiabetic and Antioxidant Effects

Anna Votano, Alessia Bonofiglio , Federica Catalano , Claudia Paone

Category: Medical Case Reports

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Within our organism, during the numerous metabolic reactions, free radicals (or ROS) are formed, unstable molecules that contain one or more unseated electrons and are responsible for oxidative stress. The organism must cope with and eliminate these free radicals that can create indiscriminate damage on biological macromolecules. To counteract their action and prevent cellular oxidation, the presence of molecules defined as antioxidants is fundamental. Some studies have seen that oxidative stress, caused by the presence of fress radicals, is related to the onset of cardiovascular disease, diabetes, tumors and other chronic diseases.

Alpha lipoic acid (ALA) is an acid know for its positive effects on health, in particular its antidiabetic and antioxidant effects, and its effects on weight loss. Given its properties, in this study we want to explain in detail the mechanisms that determine these effects, also based on what is found in the literature. Objective: Analyse the importance of alpha lipoic acid and its antidiabetic and antioxidant effects.

Design: We have based the study in a bibliographic review.

Result: The antioxidant effect is due to its ability to neutralize free radicals and oxygen reactive species (ROS) and the ability to enhance the action of other endogenous antioxidants, such as vitamin E and vitamin C. The antidiabetic effect is to improve the effectiveness of insulin and the transport of glucose into cells, thus leading to a reduction in insulin resistance.

Conclusions: With this study we have demonstrated in detail the main mechanisms by which ALA acts and determines its antioxidant and antidiabetic effects. Our body is able to defend itself against ROS thanks to the presence of natual antioxidant substances, but sometimes these are not enough, so it is necessary to take supplements. It should be remembered that ALA is not a medicine and has no healing properties but its integration can be useful for the well-being of the organism.

Keywords: Alpha Lipoic Acid, Diabetes, Antioxidant Effects, Antidiabetic Effects


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