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    <Journal>
      <PublisherName>jmedicalcasereports</PublisherName>
      <JournalTitle>Frontiers in Medical Case Reports</JournalTitle>
      <PISSN>I</PISSN>
      <EISSN>S</EISSN>
      <Volume-Issue>Volume 6; Issue 6</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>(Nov-Dec, 2025)</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>Medical Case Reports</ArticleType>
      <ArticleTitle>Naphthalene-Induced Methemoglobinemia and Hemolysis in a G6PD-Deficient Child: A Rare Case Report</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>1</FirstPage>
      <LastPage>6</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Ramesh</FirstName>
          <LastName>Mallavarapu</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Mamdouh</FirstName>
          <LastName>Swillem</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Anoud Alkindi</FirstName>
          <LastName/>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Nasser</FirstName>
          <LastName>Ezzat</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Krishna Prasad</FirstName>
          <LastName>Maram</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Betsy</FirstName>
          <LastName>Mathew</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Felipe</FirstName>
          <LastName>Caino</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Anas</FirstName>
          <LastName>Moter</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>Background: Naphthalene ingestion poses a substantial risk of oxidative hemolysis and methemoglobinemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient children, particularly in regions where household mothball use is common.&#13;
&#13;
Case Summary: A 2-year-old girl with known G6PD deficiency initially presented asymptomatic after ingesting a naphthalene ball, with normal oxygen saturation and no significant laboratory abnormalities. Within hours, she developed progressive irritability and unexplained hypoxia that showed no improvement with supplemental oxygen and occurred without respiratory distress. Severe hemolysis and methemoglobinemia were subsequently confirmed. She demonstrated rapid clinical and biochemical improvement following packed red blood cell (PRBC) transfusion, while methylene blue was avoided due to her G6PD deficiency and toxicology guidance.&#13;
&#13;
Conclusion: Close monitoring and early transfusion-based management are crucial in G6PD-deficient children with naphthalene ingestion to prevent neurological complications and ensure a good clinical outcome.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>G6PD Deficiency,Naphthalene poisoning, Oxidative hemolysis, Methemoglobenemia, Blood transfusion</Keywords>
      <URLs>
        <Abstract>https://jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=16010&amp;title=Naphthalene-Induced Methemoglobinemia and Hemolysis in a G6PD-Deficient Child: A Rare Case Report</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References>Ahmad R, Amir SH, Khan SA. Naphthalene Mothballs Poisoning Leading to Intravascular Hemolysis: A Case Report. J Emerg Med 2020; 58: e1-e3.&#13;
&#13;
Dela Cruz M, Khalid MM, Mostafa A, Ershad M, Vearrier D, McKeever R. Hemolytic Crisis following Naphthalene Mothball Ingestion in a 21-Month-Old Patient with Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency. Case Rep Pediatr 2019; 2019: 1092575.&#13;
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Eskandarani RM, Alghamdi FS. Naphthalene Toxicity in a Three-Year-Old Child Complicated by Severe Hemolytic Anemia and Mild Methemoglobinemia: A Case Report. J Emerg Med 2020; 59: e113-e117.&#13;
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Kaminecki I, Huang D. Methemoglobinemia. Pediatr Rev 2021; 42: 164-166.&#13;
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Kapoor R, Suresh P, Barki S, Mishra M, Garg MK. Acute intravascular hemolysis and methemoglobinemia following naphthalene ball poisoning. Indian J Hematol Blood Transfus 2014; 30: 317-319.&#13;
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Methemoglobinemia. UpToDate. Last accessed October 2025. Available from: https://www.uptodate.com&#13;
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Nongrum SM, Chandel AB, Varma R, Jategaonkar S, Jain M. Hemolytic Anemia and Hypoxic Brain Injury following Mothball Ingestion in a G6PD Nondeficient Infant: A Case Report. Journal of Child Science 2021; 11: e296-e298.&#13;
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Pannu AK, Singla V. Naphthalene Toxicity in Clinical Practice. Curr Drug Metab 2020; 21: 63-66.&#13;
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Trevisan A, Rossi di Schio M, Pieno M. Haemolytic anaemia after oral self-giving of naphthalene-containing oil. J Appl Toxicol 2001; 21: 393-396.</References>
      </References>
    </Journal>
  </Article>
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